PARTISIPASI PRIA DALAM PROGRAM KELUARGA BERENCANA (KB)

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Deinococcus radiodurans PriA is a Pseudohelicase

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PriA helicase and SSB interact physically and functionally.

PriA helicase is the major DNA replication restart initiator in Escherichia coli and acts to reload the replicative helicase DnaB back onto the chromosome at repaired replication forks and D-loops formed by recombination. We have discovered that PriA-catalysed unwinding of branched DNA substrates is stimulated specifically by contact with the single-strand DNA binding protein of E.coli, SSB. Th...

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Structural mechanisms of PriA-mediated DNA replication restart.

Collisions between cellular DNA replication machinery (replisomes) and damaged DNA or immovable protein complexes can dissociate replisomes before the completion of replication. This potentially lethal problem is resolved by cellular "replication restart" reactions that recognize the structures of prematurely abandoned replication forks and mediate replisomal reloading. In bacteria, this essent...

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Role of PriA in replication fork reactivation in Escherichia coli.

As a result of the work of many laboratories, a new paradigm describing the manner by which bacteria respond to repair DNA damage has emerged. This paradigm holds that under any growth condition, essentially all replication forks formed at oriC encounter DNA damage and either stall or collapse before they can complete synthesis of the genome. Maintenance of cell viability therefore requires bot...

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ژورنال

عنوان ژورنال: Marwah: Jurnal Perempuan, Agama dan Jender

سال: 2012

ISSN: 2407-1587,1412-6095

DOI: 10.24014/marwah.v11i1.502